Effects of Plant Part Substitution in a Thai Traditional Recipe on α-Glucosidase Inhibition

A Thai polyherbal antipyretic remedy, TPDM6315, consists of herbal constituents that possess anti-diabetic properties. It contains 15 plants, which the roots 3 crude drugs, Solanum indicum (R-Si), trilobatum (R-St), and Gymnopetalum integrifolium (R-Gi), are insufficiently supplied in market, while their stems or aerial parts (S-Si, S-St, S-Gi, respectively), available. This study aimed to determine properties recipe extract evaluate possible substitution those drugs. The chemical vitro -glucosidase inhibition were investigated single ingredient extracts. results indicated TPDM6315 extracts inhibited as a mixedtype inhibitor. high-performance liquid chromatography (HPLC) profiles between root stem herbs different but highly similar substituted (S-Et, containing S-Si, S-Gi) exhibited higher potency on α-glucosidase than original (R-Et, R-Si, R-St, R-Gi) (P<0.01). revealed was for inhibitory since it only partially affected overall profile raising activity extracts.&nbsp